Epidermal urocanic acid in discoid lupus erythematosus.
نویسندگان
چکیده
Sir, Ultraviolet radiation (UVR) induces isomerization of transurocanic acid (UCA), a natural component of human skin, into cis-UCA, which has been shown to suppress both delayed hypersensitivity and contact hypersensitivity (1). An autoantigen-speci®c T-cell-mediated mechanism has been proposed in both chronic cutaneous lupus erythematosus, presenting mostly as discoid lupus erythematosus (DLE), and polymorphous light eruption (PLE) (2, 3). A subnormal epidermal UCA content might theoretically lead to disease exacerbation of T-cell-mediated disorders due to less cisUCA-mediated suppression of cell-mediated autoimmune processes. To study this possibility, we examined the epidermal UCA contents of patients with DLE and compared the results with data obtained from PLE patients and control persons.
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ورودعنوان ژورنال:
- Acta dermato-venereologica
دوره 79 5 شماره
صفحات -
تاریخ انتشار 1999